发明名称 |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
摘要 |
The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.
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申请公布号 |
US2002151493(A1) |
申请公布日期 |
2002.10.17 |
申请号 |
US20010001945 |
申请日期 |
2001.11.01 |
申请人 |
PRAECIS PHARMACEUTICALS INC. |
发明人 |
OLSON GARY L.;SELF CHRISTOPHER;LEE LILY;COOK CHARLES MICHAEL;BIRKTOFT JENS;MORGAN BARRY;ARICO-MUENDEL CHRISTOPHER C. |
分类号 |
C07D303/22;A61K31/336;A61K38/00;A61K38/48;A61K47/48;A61P9/00;A61P19/02;A61P35/00;A61P37/00;A61P37/02;C07D405/14;C07K5/02;C07K5/06;C07K5/083;C07K5/09;C07K5/103;C07K14/00;C07K14/81;(IPC1-7):A61K38/16;A61K38/10;A61K38/08;A61K38/07;A61K38/06 |
主分类号 |
C07D303/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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