| 摘要 |
<p>Compounds having he general structure I are provided. X and Y are independently selected from the group consisting of CH2, N, NR9, C=O, C=S, S=O, SO¿2?, S, O, (CR?6R7)¿n, C(=O)-(CR6R7)n, and C(=S)-(CR6R7)n, where n is 1, 2, or 3. W is selected from the group consisting of (formula I) and L is selected from the group consisting of N, O, S=O, SO2, C(O), NC(O), NC(S), OC(O), OC(S), C(NR10), C(NOR10), and a covalent bond. Z?1, Z2, and Z3¿ are independently selected from the group consisting of substituted carbon and nitrogen. Compounds of formula I are agonists of the melanocortin-4 receptor ('MC-4r2) and therefore may have useful properties for controlling diseases related to MC-4r action in humans, such as obesity and type II diabetes.</p> |
