The invention provides plasmids, bacteriophages and bacterial strains comprising prophages in which some or all of the cos region has been deleted and replaced in whole or in part by a replacement sequence. The invention also provides methodologies of producing and using such products. Of particular interest are vectors, modified bacteriophages, DNA parkaging components and transducing particles which have broad range infectivity of Actinomycetes bacteria and in particular Streptomyces strains.
申请公布号
WO02081679(A2)
申请公布日期
2002.10.17
申请号
WO2002GB01651
申请日期
2002.04.09
申请人
THE UNIVERSITY OF NOTTINGHAM;FINNIS, CHRISTOPHER, JOHN, ARTHUR;SMITH, MARGARET, CAROLINE, MACHIN