| 发明名称 |
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR SYNTHESE VON DIOXOLAN-NUKLEOSIDE MIT BETA-STRUKTUR |
| 摘要 |
<p>The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about -10 DEG C. wherein R1 and L are as defined herein.</p> |
| 申请公布号 |
DE69620042(T2) |
申请公布日期 |
2002.10.17 |
| 申请号 |
DE1996620042T |
申请日期 |
1996.12.13 |
| 申请人 |
SHIRE BIOCHEM INC., LAVAL |
发明人 |
MANSOUR, TAREK;CIMPOIA, ALEX;BEDNARSKI, KRZYSTOF |
| 分类号 |
C07D473/00;C07D317/10;C07D405/04;C07D473/04;C07D473/16;C07D473/18;C07D473/30;C07D473/32;C07D473/34;C07D473/40;C07D487/04;C07H;(IPC1-7):C07D411/04;C07H19/06 |
主分类号 |
C07D473/00 |
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