发明名称 |
Compositions and methods for tissue specific gene regulation therapy |
摘要 |
This invention relates to a recombinant nucleic acid vector comprising a first expression cassette comprising a first promoter operably linked to a nucleic acid sequence encoding a syncytium-inducing polypeptide, wherein the first expression cassette is flanked on either side by a site recognized by a recombinase. The invention also includes a second expression cassette comprising a tissue-specific promoter operably linked to a nucleic acid sequence encoding a recombinase. The invention also includes cells and compositions including these expression cassettes and methods of reducing tumor volume by expression of these expression cassettes.
|
申请公布号 |
US2002150556(A1) |
申请公布日期 |
2002.10.17 |
申请号 |
US20010822634 |
申请日期 |
2001.03.30 |
申请人 |
VILE RICHARD G.;HARRINGTON KEVIN;MURPHY STEVEN;BATEMAN ANDREW |
发明人 |
VILE RICHARD G.;HARRINGTON KEVIN;MURPHY STEVEN;BATEMAN ANDREW |
分类号 |
A61K48/00;C12N15/867;(IPC1-7):A61K48/00;C12N15/86;C12N5/08 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|