| 摘要 |
<p>The present invention relates to a transgenic animal having a disruption of at least one allele of the Ceacam 1 gene and method of making same. More particularly, the present invention relates to transgenic mouse whose germ cells and somatic cells contain a knockout mutation in DNA encoding CEACAM1a or CEACAM1b. In a particular embodiment, mice containing a disruption of at least one of the Ceacam 1 gene present a reduced expression of the CEACAM1a protein. The present invention also relates to a transgenic mouse comprising a disruption of the Ceacam1 gene wherein the mouse expresses at least a reduced level of CEACAM1a relative to a corresponding wild-type mouse and methods of making same.</p> |
