Adsorbent for oral administration

摘要

An adsorbent (A) comprises a porous spherical carbonaceous substance. The diameter of (A) is (0.01 - 1, preferably 0.02 - 0.8) mm, specific surface area (at least 700, preferably 700 - 2500) m 2>/g determined by BET method, volume of pores (0.04 - =0.1) ml/g having pore diameter (20 - 15000) nm, total amount of acidic groups (0.3 - 1.2) meq/g and total amount of basic group (0.2 - 0.7) meq/g. An independent claim is included for a pharmaceutical composition comprising (A) and a carrier or diluent. ACTIVITY : Nephrotropic; Hepatotropic; Gastrointestinal. An absorbent (3 g/day) was orally administered to a male patient (79 years) suffering from liver dysfunction showed GOT (glutamic-oxaloacetic transaminase) (47 units) and GPT (glutamic-pyruvic transaminase) (66 units). Four months later GOT was lowered to 21 units and GPT was lowered to 24 units. The administration was continued and after 7 months the GOT was lowered to 18 units and GPT was lowered to 21 units. MECHANISM OF ACTION : None given.