发明名称 |
BIOCOMPATIBLE PROSTHETIC TISSUE |
摘要 |
Crosslinked tissue is contacted with one or more toxicity reducing solutions to remove cytotoxicity associated with the crosslinking process. In particular, crosslinked tissue can be contacted with an inorganic sulfur-oxygen group to form chemical adducts of aldehydes and the inorganic sulfur-oxygen group. Preferably, the cytotoxicity reduced crosslinked tissue has no residual cytotoxicity. In preferred embodiments, a plurality of toxicity reducing agents are used to detoxify the tissue. Preferred toxicity reducing agents include, for example, inorganic sulfur-oxygen ions, such as bisulfate and thiosulfate, organic sulfates, amines, ammonia/ammonium, and surfactants. |
申请公布号 |
EP1248655(A1) |
申请公布日期 |
2002.10.16 |
申请号 |
EP20000986724 |
申请日期 |
2000.12.22 |
申请人 |
ST. JUDE MEDICAL, INC. |
发明人 |
ASHWORTH, PAUL, E.;OGLE, MATTHEW, F.;MCTAVISH, DANIEL, P.;KELLY, SHEILA, J.;JOHNSON, ANDREA, L. |
分类号 |
A61F2/06;A61F2/24;A61L27/36;A61L27/50;(IPC1-7):A61L27/36 |
主分类号 |
A61F2/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|