发明名称 |
Cyclosporiine particles |
摘要 |
Pharmaceutical compositions containing solid cyclic oligopeptide cyclosporine microparticles are prepared by applying energy input to solid cyclic oligopeptide cyclosporine in the presence of phospholipid and one or more non-ionic, anionic or cationic second surface modifiers. The microparticles consist essentially of a solid cyclic oligopeptide cyclosporine core coated with a combination of phospholipid and at least one second surface modifier. The combination of phospholipid and second surface modifier(s) provide volume-weighted mean particle size values of solid cyclic oligopeptide cyclosporine particles that are about 50% smaller than cyclic oligopeptide cyclosporine particles produced in the presence of the phospholipid and without the presence of the second surface modifier(s) using the same energy input.
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申请公布号 |
US6465016(B2) |
申请公布日期 |
2002.10.15 |
申请号 |
US20000750218 |
申请日期 |
2000.12.29 |
申请人 |
RESEARCH TRIANGLE PHARMACEUTICALS |
发明人 |
PARIKH INDU;SNOW ROBERT A. |
分类号 |
A61K9/14;(IPC1-7):A61K9/14;A61K47/32;G01N33/92 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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地址 |
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