发明名称 |
LIGAND FÄHIG ZUR BINDUNG AN DER ADENOSINEDEAMINASE-BINDUNGSSTELLE VON CD26 |
摘要 |
The invention relates to a ligand or functional derivative thereof, with at least one specificity for the adenosine deaminase (ADA) binding site of CD26, being for example a monoclonal antibody or a modified version of adenosine deaminase. The functional derivative can be an Fab' -, Fab-, F(ab)2-, a scFv - or Fv-fragment of the monoclonal antibody or a chimeric antibody. Apart from this the functional derivative can be a conjugate between the ligand or a functional component thereof and a secondary molecule. The ligands according to the invention can be used as a therapeutic agent for stimulating the proliferation of T-lymphocytes, as an immuno-suppressing agent, as a diagnostic agent in immuno-enzymatic assays, for monitoring malignantly transformed melanocytes or in imaging techniques or as therapeutic agent against HIV-infection. |
申请公布号 |
AT225808(T) |
申请公布日期 |
2002.10.15 |
申请号 |
AT19950900671T |
申请日期 |
1994.11.04 |
申请人 |
EUROGENETICS N.V.;UNIVERSITAIRE INSTELLING ANTWERPEN |
发明人 |
DE MEESTER, INGRID;VAN HAM, GUIDO;KESTENS, LUC;VANHOOF, GRETA;VERHELST, PEGGY;GOOSSENS, FILIP;HENDRIKS, DIRK;BORLOO, MARIANNE;HAEMERS, ACHIEL;BOSMANS, EUGENE;SCHARPE, SIMON |
分类号 |
A61K38/00;C07K16/28;C07K16/40;C12N9/78 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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