ENTRAPMENT OF NUCLEIC ACID SEQUENCING TEMPLATE IN SAMPLE MIXTURES BY ENTANGLED POLYMER NETWORKS

摘要

A capillary electrophoresis system and method of electrokinetically loading a capillary electrophoresis sample into a separation medium in a capillary tub e in which an entangled polymer matrix is formed having the sample embedded therein. Th e matrix has a mesh size effective to retard movement of macromolecules such a s DNA sequencing templates through the matrix when an electric field is applied across the matrix. The entangled polymer matrix is formed by a linear polymer having a molecular weight of at least 20KDalrons.