| 发明名称 |
Hydroxamic and carboxylic acid derivatives |
| 摘要 |
The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with matrix metalloproteinase, ADAM or ADAM-TS enzymes, a condition that is mediated by TNF alpha or a condition involving a membrane-shedding event that is mediated by a metalloproteinase. Compounds of the invention are of formula Iwhereinn=0 or 1;m=0 or 1;X is S(O)1-2;Y is OH or NHOH;W is aryl or heteroaryl;and the other groups are as defined herein.
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| 申请公布号 |
US6465468(B1) |
申请公布日期 |
2002.10.15 |
| 申请号 |
US20000623835 |
申请日期 |
2000.03.22 |
| 申请人 |
DARWIN DISCOVERY LIMITED |
发明人 |
BAXTER ANDREW DOUGLAS;OWEN DAVID ALAN;BATTY DUNCAN;WATSON ROBERT JOHN |
| 分类号 |
C07D295/22;A61K31/18;A61K31/192;A61K31/343;A61K31/445;A61K31/472;A61K31/495;A61K31/496;A61P1/02;A61P1/04;A61P1/14;A61P7/00;A61P7/02;A61P9/00;A61P9/02;A61P9/04;A61P9/10;A61P9/12;A61P11/00;A61P11/02;A61P11/06;A61P15/00;A61P17/00;A61P17/06;A61P19/00;A61P19/02;A61P19/10;A61P25/00;A61P25/06;A61P27/02;A61P27/14;A61P29/00;A61P31/00;A61P31/18;A61P35/00;A61P35/04;A61P37/00;A61P37/02;A61P43/00;C07C311/13;C07C311/17;C07C311/21;C07D211/96;C07D213/74;C07D215/58;C07D217/08;C07D295/26;C07D307/79;C07D307/81;(IPC1-7):C07C311/13;A61K31/16 |
主分类号 |
C07D295/22 |
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