New substd. borate(s) - useful as intermediates for 8-alkoxy-quinoline carboxylic acid medicaments

摘要

(6,7-substd.-8-alkoxy-1- cyclopropyl-1,4-dihydro-4-oxo -3- quinolinecarboxylic acid -03, 04) bis (acyloxy-o) borates of formula (I) and their salts and hydrates are new. In (I), X = halogen, R = 2-6C aliphatic acyloxy opt. substd. by halogen or 7-11C aromatic acyloxy, R1 = lower alkyl, R2 = H, halogen, NH2 or NO2, Z = halogen cpd (II), azelidino, pyrrolidino, 3-hydroxypyrrolidino, piperidino, morpholino, or thiomorpholino, n = 1 or 2, R3 = H, lower alkyl, acyl, alkoxycarbonyl or aralkyl, R4, R5 = H, opt. substd. lower alkyl, cycloalkyl or phenyl, K = 0, 1 or 2, L = 0,1 or 2, m = 0 or 1, R6 = H, halogen, lower alkyl or PH, R7 = H or opt. substd. lower alkyl, R8 = H, lower alkyl, acyl, alkoxycarbonyl or aralkyl.