发明名称 |
PREPARATION OF PRAZIQUANTEL USING PHTHALIMIDE |
摘要 |
PURPOSE: Provided is a method of preparing Praziquantel which has an excellent effect as a therapeutic agent for distoma hepaticum and pulmonary distomiasis, by using phthalimide instead of aminoacetal used in a conventional method. CONSTITUTION: The preparation method comprises: a) obtaining N-substituted acetylalkyl amine compound like, 2-chloro-N-phenethylacetamide of the formula(3) by reacting arylalkylamine of formula(2) with haloacetyl halide; b) preparing the compound of formula(4), N-phenethylacetamide, by reacting the compound of formula(3) with phthalimide; c) obtaining the compound of formula(5) by reacting the compound represented by formula(4) with hydrazine monohydrate; d) obtaining the compound of formula(6), 2-((2,2-dimethoxyethyl)amino)-N-phenethylacetamide by reacting the compound of formula(5) with bromoacetal and alkylating acetal to amino group; e) preparing the compound of formula(7), 1,2,3,6,7,11b-hexahydro-4N-pyrazino(1,1-a)isoquinoline-4-one by cyclizing the compound of formula(6) with acid; and f) obtaining Praziquantel by alkylating the compound of formula(6).
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申请公布号 |
KR20020076486(A) |
申请公布日期 |
2002.10.11 |
申请号 |
KR20010016346 |
申请日期 |
2001.03.28 |
申请人 |
CHO, SU DONG;FINE TECH CO., LTD. |
发明人 |
AHN, CHEOL JIN;CHO, SU DONG;HUH, EUN JU;JU, U HONG;KIM, HEUNG JAE;SHIN, DONG SU;SONG, SANG YONG |
分类号 |
C07D471/04;(IPC1-7):C07D471/04 |
主分类号 |
C07D471/04 |
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