摘要 |
PURPOSE: Provided are methods for identifying variations that occur in the human genome and relating these variations to the genetic bases of phenotype such as disease resistance, disease susceptibility or drug response. The methods allow for identification of variants, identification of SNPs, determination of SNP haplotype blocks, determining SNP haplotype patterns, and further, identification of informative SNPs for each pattern, which affords genetic data compression. CONSTITUTION: A method for selecting SNP haplotype patterns, comprises the steps of: isolating a substantially identical nucleic acid strand from a plurality of different origins for analysis; determining more than one SNP location in each nucleic acid strand; identifying SNP locations in the nucleic acid strands that are linked, wherein the linked SNP locations form a SNP haplotype block; identifying isolate SNP haplotype blocks; identifying SNP haplotype patterns that occur in each SNP haplotype block and isolate SNP haplotype block; and selecting each identified SNP haplotype pattern that occurs in at least two of the substantially identical nucleic acid strands from different origins. |