发明名称 |
USE OF HERPESVIRUSES, HERPESVIRUS PROTEINS AND NUCLEIC ACIDS ENCODING THE PROTEINS TO INHIBIT CCR5-TROPIC HIV-1 INFECTION AND REPLICATION |
摘要 |
It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.
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申请公布号 |
WO02078740(A1) |
申请公布日期 |
2002.10.10 |
申请号 |
WO2002US10048 |
申请日期 |
2002.03.28 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH;MARGOLIS, LEONID, B.;GRIVEL, JEAN-CHARLES;LUSSO, PAOLO |
发明人 |
MARGOLIS, LEONID, B.;GRIVEL, JEAN-CHARLES;LUSSO, PAOLO |
分类号 |
A61K35/76;A61K38/16;A61K48/00;(IPC1-7):A61K39/395;A61K39/21;C07K16/00 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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