摘要 |
(A) Cmpds. of general formula (I):- - R' = H - R2 = (> 1C ) alkyl - or both R' and R2 = alkyl - X = O, S, SO, or SO2. - and at least one ring carries at least one substit. e.g. halogen, alkyl, haloalkyl, alkoxy, or NO2. - (B) Esters, amides and salts of (I). - Anti-inflammatories. - 2-Chloro-6-phenylphenol (30 pts.) was dissolved in EtOH (100 pts.) contng. Na (3.45 pts.), alpha-bromo-alpha-methylpropionate (29 pts.) added, and refluxed 4 hrs., cooled, evapd., dissolved in H2O (25 pts.) and EtOH (150 pts.) contng. KOH (25 pts.), refluxed 2 hrs., cooled, filtered, the residue suspended in H2O, acidified with 20% HCl, filtered, and recryst. from MeOH-H2O-HCl, giving (I), m.p. 134-5 deg.
|