| 摘要 |
DNA vaccine (A) against pathogens that affect pets and sports animals comprises a plasmid containing a sequence (I), expressible in vivo, that encodes an immunogen from the relevant pathogen and a cationic lipid (II) containing a quaternary ammonium salt, particularly DMRIE (N-(2-hydroxyethyl)-N,N-dimethyl-2,3-bis(tetradecyloxy)-1-propanammoni um). (II) have formula R1-O-CH2-CH(OR1)-CH2-N<+>(Me)2-R2-X R1 = 12-18C linear aliphatic group, saturated or unsaturated; R2 = 2-3C aliphatic group; and X = hydroxy or amino An Independent claim is also included for a multivalent vaccine (A') containing (A) plus a classical inactivated, live but attenuated, subunit or recombinant vaccine. |
