发明名称 |
Naphthostyrils |
摘要 |
Disclosed are novel naphthostyrils of formula These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing such compounds, methods for the treatment and/or prevention of cancer using such compositions, and intermediates useful in the preparation of the compounds of formula I.
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申请公布号 |
US2002147343(A1) |
申请公布日期 |
2002.10.10 |
申请号 |
US20020043732 |
申请日期 |
2002.01.10 |
申请人 |
CHEN YI;DERMATAKIS APOSTOLOS;KONZELMANN FREDERICK MARTIN;LIU JIN-JUN;LUK KIN-CHUN |
发明人 |
CHEN YI;DERMATAKIS APOSTOLOS;KONZELMANN FREDERICK MARTIN;LIU JIN-JUN;LUK KIN-CHUN |
分类号 |
A61K31/403;A61K31/4045;A61K31/454;A61K31/496;A61K31/5377;A61P1/00;A61P11/00;A61P13/08;A61P15/00;A61P35/00;A61P43/00;C07B61/00;C07D401/04;C07D401/14;C07D403/04;C07D403/06;C07D403/14;(IPC1-7):C0743/14;C0743/02 |
主分类号 |
A61K31/403 |
代理机构 |
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代理人 |
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地址 |
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