摘要 |
The present invention provides a method of determining a risk of pouchitis development following a surgical procedure where an internal pouch is created in a patient with ulcerative colitis. The method is practiced by determining in the patient the presence or absence of a pouchitis-associated allele linked to an interferon gamma receptor locus, where the presence of the pouchitis-associated allele indicates an increased risk of pouchitis development. The interferon gamma receptor locus to which the pouchitis-associated allele is linked can be, for example, an interferon gamma receptor 1 gene. A pouchitis-associated allele useful in the invention can be, for example, an allele located within the sixth intron of the interferon gamma receptor 1 gene, such as a FA1 microsatellite 171 allele. |
申请人 |
CEDARS-SINAI MEDICAL CENTER;TAYLOR, KENT, D.;YANG, HUIYING;ROTTER, JEROME, I.;FLESHNER, PHILLIP, R. |
发明人 |
TAYLOR, KENT, D.;YANG, HUIYING;ROTTER, JEROME, I.;FLESHNER, PHILLIP, R. |