发明名称 |
Regulatory nucleic acid for the ABC1 gene, molecules modifying its activity and therapeutic uses |
摘要 |
The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol metabolism, inducing diseases such as atherosclerosis. The invention also relates to nucleotide constructs comprising a polynucleotide which encodes a polypeptide or a nucleic acid of interest, placed under the control a regulatory nucleic acid for the ABC1 gene. The invention also relates to recombinant vectors, transformed host cells and nonhuman transgenic mammals comprising a nucleic acid which regulates the transcription of the ABC1 gene or an abovementioned nucleotide construct, as well as methods for screening molecules or substances which are capable of modifying the activity of the regulatory nucleic acid for the ABC1 gene.
|
申请公布号 |
US2002146792(A1) |
申请公布日期 |
2002.10.10 |
申请号 |
US20010846456 |
申请日期 |
2001.05.02 |
申请人 |
ROSIER-MONTUS MARIE-FRANCOISE;PRADES CATHERINE;LEMOINE CENDRINE;NAUDIN LAURENT;DENEFLE PATRICE;DUVERGER NICOLAS;BREWER BRYAN;REMALEY ALAN;SANTAMARINA-FOJO SYLVIA |
发明人 |
ROSIER-MONTUS MARIE-FRANCOISE;PRADES CATHERINE;LEMOINE CENDRINE;NAUDIN LAURENT;DENEFLE PATRICE;DUVERGER NICOLAS;BREWER BRYAN;REMALEY ALAN;SANTAMARINA-FOJO SYLVIA |
分类号 |
A01K67/027;A61K38/00;A61K45/00;A61P3/06;A61P9/10;C07K14/705;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12Q1/68;(IPC1-7):A01K67/00;C12N9/02;C07H21/04 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|