3-SUBSTITUTED INDOLES AS CHEMOKINE ANTAGONISTS

摘要

A compound of the formula (I): in which: R1 is (C¿1-6?)alkyl, optionally substituted aryl or optionally substituted heteroaryl; R?2 and R3¿ which may be the same or different are selected from the group consisting of hydrogen, halogen, cyano(C¿1?-6)alkyl, (C3-7)cycloalkyl, (C1-6)alkoxy, halo(C1-6)alkyl, hydroxy, amino, mono- or di-(C1-6)alkylamino, acylamino, nitro, carboxy, (C1-6)alkoxycarbonyl, (C1-6)alkenyloxycarbonyl, (C1-6)alkoxycarbonyl(C1-6)alkyl, carboxy(C1-6)alkyl, (C1-6)alkylcarbonyloxy, carboxy(C1-6)alkyloxy, (C1-6)alkoxycarbonyl(C1-6)alkoxy, (C1-6)alkylthio, (C1-6)alkylsulphinyl, (C1-6)alkylsulphonyl, sulphamoyl, mono- and di-(C1-6)-alkylsulphamoyl, carbamoyl, mono- and di-(C1-6)alkylcarbamoyl, ureido, (C1-6)alkylsulphonamido, arylsulphonamido, aryl, aryl(C1-6)alkyl, aryl(C1-6)alkoxy, aryloxy and heterocyclyl; R?4¿ is hydrogen or C¿(1-6)?alkyl; R?5 and R6¿ which may be the same or different are hydrogen or C¿(1-6)?alkyl, or together with the carbon atoms of the ring to which they are attached from the bridging 5- to 7 membered ring; W is a bond, C(1-6)alkylene optionally substituted by C(1-6)alkyl, CH2O, CH2S OR trans-(E)-CR?7¿=CH-Y- in which R7 is hydrogen or (C¿1-6?)alkyl and Y is a bond, trans-(E)-CH=CH-, or CO; m and n are each integers from 1 to 3; p and q are each independently 1 or 2; and x is an integer from 1 to 4; or a pharmaceutically acceptable salt thereof. For use in the manufacture of a medicament for use in the treatment of inflammatory conditions with monocyte and/or lymphocyte involvement.