| 摘要 |
The invention concerns areas involving eukaryotic cell culture and tissue engineering, particularly fibrin-containing keratinocyte suspensions and fibroblast suspensions based on two constituents. The invention also relates to the use of the inventive keratinocyte suspensions and fibroblast suspensions for the <i>in situ</i> production of autologous (cell) transplants. The invention particularly relates to the use of transplants for treating patients with chronic ulcers of different origins, with burn wounds, post-traumatic wound defects, and for covering defects of extensive, benign, naevoid skin changes and of scars after prior dermabrasion. The invention also relates to the use of the inventive keratinocyte suspensions and fibroblast suspensions for treating postoperative wound defects after dermabrasion, excision or laser ablation of skin defects. The invention additionally relates to the accordingly produced transplants themselves, which contain keratinocytes or fibroblasts, to methods for producing the two-constituent keratinocyte composition or fibroblast composition, and to methods for producing collagen-free two-constituent compositions. |
