| 发明名称 |
Methods for producing and purifying recombinant alpha-L-iduronidase |
| 摘要 |
The present invention provides a recombinant human alpha-L-iduronidase and biologically active fragments and muteins thereof with a purity greater than 99%. The present invention further provides large-scale methods to produce and purify commercial grade recombinant human alpha-L-iduronidase enzyme thereof.
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| 申请公布号 |
US2002146802(A1) |
申请公布日期 |
2002.10.10 |
| 申请号 |
US20010993038 |
申请日期 |
2001.11.13 |
| 申请人 |
QIN MINMIN;CHAN WAI-PAN;CHEN LIN;FITZPATRICK PAUL A.;HENSTRAND JOHN M.;WENDT DAN J.;ZECHERLE GARY N.;STARR CHRISTOPHER M.;KAKKIS EMIL D. |
发明人 |
QIN MINMIN;CHAN WAI-PAN;CHEN LIN;FITZPATRICK PAUL A.;HENSTRAND JOHN M.;WENDT DAN J.;ZECHERLE GARY N.;STARR CHRISTOPHER M.;KAKKIS EMIL D. |
| 分类号 |
C12N15/09;A61K9/08;A61K38/00;A61K38/43;A61K38/47;A61K47/02;A61K47/10;A61K48/00;A61P3/00;A61P19/00;A61P43/00;C12N9/24;C12N9/88;C12N15/56;(IPC1-7):C12N9/24;C07H21/04;C12P21/02;C12N5/06;C12N15/87 |
主分类号 |
C12N15/09 |
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