| 摘要 |
<p>The invention provides devices, device configurations and method for improved sensitivity, detection level and efficiency in mass spectrometry particularly as applied to biological molecules, including biological polymers, such as proteins and nucleic acids. In one aspect, the invention relates to charged droplet sources having a piezoelectric member capable of generating a pulsed pressure wave. In another aspect, the invention relates to charged particle sources having a droplet trap for regulating droplet flow rate. In addition, the invention relates to an ion source (808) having an aerodynamic ion lens system (550) for high efficiency ion transport to a charged particle analyzer, particularly a mass analyzer (820). Devices of this invention allow mass spectral analysis of a single charged droplet and can be combined with any mass analyzer, but are a particularly benefit with time of flight mass spectrometer (820).</p> |
