发明名称 |
ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES |
摘要 |
This invention relates to novel alpha -conotoxin-like peptides comprising the following sequence of amino acids: Xaa1CCSXaa2Xaa3Xaa4CXaa5Xaa6Xaa7Xaa8Xaa9Xaa10Xaa11C-NH2 in which Xaa1 is G or D; Xaa3 is proline, hydroxyproline or glutamine; each of Xaa2 to Xaa8 and Xaa11 is independently any amino acid; Xaa9 is proline, hydroxyproline or glutamine; Xaa10 is aspartate, glutamate or gamma -carboxyglutamate; Xaa11 is optionally absent; and the C-terminus is optionally amidated, with the proviso that the peptide is not alpha -conotoxin Ep1 or alpha -conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke. |
申请公布号 |
WO02079236(A1) |
申请公布日期 |
2002.10.10 |
申请号 |
WO2002AU00411 |
申请日期 |
2002.03.28 |
申请人 |
LIVETT, BRUCE;KHALIL, ZEINAB;GAYLER, KENWYN;DOWN, JOHN |
发明人 |
LIVETT, BRUCE;KHALIL, ZEINAB;GAYLER, KENWYN;DOWN, JOHN |
分类号 |
C12N15/09;A61K38/00;A61P1/02;A61P17/02;A61P19/02;A61P21/00;A61P25/00;A61P25/02;A61P25/04;A61P25/08;A61P25/16;A61P25/28;A61P25/34;A61P29/00;A61P35/00;A61P43/00;C07K14/435 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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