| 摘要 |
An isolated nucleic acid sequence encoding a polypeptide functionally homologous to the wild type form of the Parkin polypeptide or a fragment of said polypeptide, the amino acid sequence of said polypeptide differing from the wild type amino acid sequence at least in including a mutation at Asp 126, wherein the said nucleic acid sequence is at least 70% identical to a nucleic acid sequence encoding the wild type Parkin polypeptide, and a mutated Parkin polypeptide. |
