| 摘要 |
Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, in which E is formula (II), X is N or CH, W is -NR>16<R>17<, -NR>16<C(=O)R>22<, -NR>16<CO>2<R>22<, -OR>23<, or a heteroaryl or heterocyclo group as defined in the specification, and R>1< through R>12<, R>16<, R>17<, R>22<, R>23<, x, y, and z are as defined in the specification, are useful as modulators of melanocortin receptors, particularly MC-1R and MC-4R. |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY;YU, GUIXUE;MACOR, JOHN;HERPIN, TIMOTHY;LAWRENCE, R, MICHAEL;MORTON, GEORGE, C;RUEL, REJEAN;POINDEXTER, GRAHAM, S;RUEDIGER, EDWARD, H;THIBAULT, CARL |
发明人 |
YU, GUIXUE;MACOR, JOHN;HERPIN, TIMOTHY;LAWRENCE, R, MICHAEL;MORTON, GEORGE, C;RUEL, REJEAN;POINDEXTER, GRAHAM, S;RUEDIGER, EDWARD, H;THIBAULT, CARL |
