| 摘要 |
organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to 3-demethylthiocolchicine derivatives of the general formula (I) where R can mean , to methods of their synthesis, pharmaceutical compositions containing thereof and their using in the field of rheumatology and orthopedics for preparing medicinal preparations showing myorelaxing and an anti-inflammatory activities. EFFECT: improved methods of synthesis, valuable medicinal properties. 9 cl, 1 tbl, 1 sch, 7 ex
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