2-(pyrazol-3-yl)carbapenem derivatives

摘要

A compound of formula (I): in which R is: wherein Ralpha is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; Rbeta is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; or Ralpha and Rbeta together form an optionally substituted 5 or 6 membered heterocyclic ring with or without additional heteroatoms; R1 is (C1-6)alkyl which is unsubstituted or substituted by fluoro, a hydroxy group which is optionally protected by a removable hydroxy protecting group, or by an amino group which is optionally protected by a removable amino protecting group; R2 is hydrogen or methyl; and -CO2R3 is carboxy or a carboxylate anion or the group R3 is a removable carboxy protecting group. This invention also relates to processes for its preparation, intermediates and pharmaceutical compositions comprising compounds of formula (I). Compounds of formula (I) which include pharmaceutially acceptable salts or pharmaceutially acceptable in vivo hydrolysable esters thereof have a broad spectrum of anti-bacterial activity and show good stability towards DHP-1.