摘要 |
The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which mayor may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the <i>cis</i> configuration. |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;GRUBBS, ROBERT, H.;CHATTERJEE, ARNAB, K.;CHOI, TAE-LIM;GOLDBERG, STEVEN, D.;LOVE, JENNIFER, A.;MORGAN, JOHN, P.;SANDERS, DANIEL, P.;SCHOLL, MATTHIAS;TOSTE, F., DEAN;TRNKA, TINA, M. |
发明人 |
GRUBBS, ROBERT, H.;CHATTERJEE, ARNAB, K.;CHOI, TAE-LIM;GOLDBERG, STEVEN, D.;LOVE, JENNIFER, A.;MORGAN, JOHN, P.;SANDERS, DANIEL, P.;SCHOLL, MATTHIAS;TOSTE, F., DEAN;TRNKA, TINA, M. |