| 发明名称 |
NOVEL PROLINES AS ANTIMICROBIAL AGENTS |
| 摘要 |
Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula:wherein Ar is aryl and heteroaryl; L is -C(O)N(Q)CH2-, or -CR10R11OCR12R13-; Q is hydrido, -(CH2)mCO2H and -(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents. |
| 申请公布号 |
EP1176959(A4) |
申请公布日期 |
2002.10.09 |
| 申请号 |
EP20000932063 |
申请日期 |
2000.05.05 |
| 申请人 |
MERCK & CO., INC.;CUBIST PHARMACEUTICALS, INC. |
发明人 |
LEEMAN, AARON, H.;HAMMOND, MILTON, L.;MALETIC, MILANA;SANTORELLI, GINA, M.;WADDELL, SHERMAN, F.;FINN, JOHN;MORYTKO, MICHAEL;RAM, SIYA;KEITH, DENNIS |
| 分类号 |
C07D487/04;A61K31/4184;A61K31/42;A61K31/427;A61K31/437;A61K31/519;A61P31/00;A61P31/04;A61P31/10;A61P43/00;C07D403/12;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07D471/04;C07D473/00;C07D473/34 |
主分类号 |
C07D487/04 |
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