| 发明名称 |
FHIT PROTEINS AND NUCLEIC ACIDS AND METHODS BASED THEREON |
| 摘要 |
The present invention relates to nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The FHIT gene sequence is mutated in diseases involving cell overproliferation, particularly malignancies of the digestive tract. The present invention further relates to the use of FHIT genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with cell overproliferation. |
| 申请公布号 |
EP0892809(A4) |
申请公布日期 |
2002.10.09 |
| 申请号 |
EP19970905817 |
申请日期 |
1997.02.07 |
| 申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
CROCE, CARLO, M.;HUEBNER, FRANCES, K. |
| 分类号 |
C12N15/02;A61K31/00;A61K31/70;A61K31/7088;A61K38/00;A61K48/00;A61P1/00;A61P11/00;A61P13/00;A61P13/12;A61P15/00;A61P19/00;A61P35/00;C07K14/47;C07K16/18;C07K19/00;C12N1/21;C12N5/10;C12N15/00;C12N15/01;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12Q1/68 |
主分类号 |
C12N15/02 |
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