LIPASES WITH IMPROVED SURFACTANT RESISTANCE

摘要

PCT No. PCT/EP95/01687 Sec. 371 Date Oct. 22, 1996 Sec. 102(e) Date Oct. 22, 1996 PCT Filed Apr. 28, 1995 PCT Pub. No. WO95/30744 PCT Pub. Date Nov. 16, 1995The present invention provides mutant lipases which retain lipase activity, but have improved surfactant resistance and are thus highly advantageous for use in detergent compositions. Preferred lipases of this type include modified functional forms of a lipase of Pseudomonas alcaligenes having one or more amino acid substitutions at or near the surface of the lipase which effect interaction of the hydrophobic portions of surfactant molecules with initiation sites on the enzyme for surfactant denaturation.