PREPARATION OF CIS-4-O-PROTECTED-2-CYCLOPENTENOL DERIVATIVES

摘要

The present invention relates to a novel process for preparing cis-4-O- protected-substituted-2-cyclopentenol derivatives comprising, (a) dissolving a 4-O-protected-2-cyclopentenone in a suitable organic solvent; and (b) treati ng the solution with a suitable Lewis acid and a suitable reducing agent at a temperature of from about -100 ~C to about 20 ~C. The cis-4-O-protected- substituted-2-cyclopentenol derivatives are useful intermediates in the preparation of various cyclopentanyl and cyclopentenyl purine analogs which are useful as immunosuppressants and in the preparation of various prostaglandins.