| 发明名称 |
Crystalline IL-6 and models of the molecular structure of IL-6 |
| 摘要 |
Crystallographic and NMR solution structures of human IL-6 are reported. The invention provides models and systems incorporating such structures which are useful for identifying IL-6/IL-6 receptor interactions and for identification of agonists and antagonists of such interactions. Crystalline human IL-6 is also provided.
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| 申请公布号 |
US6461604(B1) |
申请公布日期 |
2002.10.08 |
| 申请号 |
US20000499148 |
申请日期 |
2000.02.07 |
| 申请人 |
GENETICS INSTITUTE, LLC |
发明人 |
SOMERS WILLIAM S.;STAHL MARK L.;SEEHRA JASBIR S.;XU GUANG-YI;MCDONAGH THOMAS E.;YU HSIANG-AI;HONG JIN |
| 分类号 |
C07K14/54;(IPC1-7):C07K1/30;C07K1/54;A61K38/20 |
主分类号 |
C07K14/54 |
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