ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PRODUCTION THEREOF

摘要

PURPOSE: A process of preparing new 2,4-pyrimidinedione derivatives having high antiviral activity against Hepatitis B virus and low toxicity is provided. Whereby, the composition can be effectively used in treatment and prevention of Hepatitis B virus. CONSTITUTION: The titled compound of the formula 1 is prepared by alkylation of a compound of formula 2 with a compound of a formula R-X or 3b. In formula, R, R2 and R3 are each independently H or C1-8 alkyl, with the proviso that R1, R2 and R3 are the same at the same time, A represents two hydrogen atoms, CH2, O, S or NH, Ar represents phenyl or naphtyl capable of being substituted by a substituent selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, amino and C1-4 alkylamino, X represents halogen.