发明名称 |
Methods and compositions for inhibiting neoplastic cells growth |
摘要 |
The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.
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申请公布号 |
US2002142949(A1) |
申请公布日期 |
2002.10.03 |
申请号 |
US20000751877 |
申请日期 |
2000.12.28 |
申请人 |
YEN FRANCES;DENISON BLAKE;BOUR BARBARA;BIHAIN BERNARD;EDWARDS JEAN-BAPTISTE DUMAS MILNE;DUCLERT AYMERIC;BOUGUELERET LYDIE;EBBETS-REED DANA;SALTER-CID LUISA |
发明人 |
YEN FRANCES;DENISON BLAKE;BOUR BARBARA;BIHAIN BERNARD;EDWARDS JEAN-BAPTISTE DUMAS MILNE;DUCLERT AYMERIC;BOUGUELERET LYDIE;EBBETS-REED DANA;SALTER-CID LUISA |
分类号 |
A61K38/00;C07K14/47;C12N15/12;C12N15/62;(IPC1-7):A61K38/17;C07H21/04;C12P21/02;C12N5/06;C07K14/435 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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