| 发明名称 |
Prodrugs of thrombin inhibitors |
| 摘要 |
There is provided compounds of formula I, <paragraph lvl="0"><in-line-formula>R1O(O)C-CH2-(R)Cgl-Aze-Pab-R2 I </in-line-formula>wherein R1 and R2 have meanings given in the description, which are usefull as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants. |
| 申请公布号 |
US2002142968(A1) |
申请公布日期 |
2002.10.03 |
| 申请号 |
US20020074008 |
申请日期 |
2002.02.14 |
| 申请人 |
ASTRAZENECA AB |
发明人 |
ANTONSSON THOMAS;GUSTAFSSON DAVID;HOFFMANN KURT-JURGEN;NYSTROM JAN-ERIK;SORENSEN HENRIK;SELLEN MIKAEL |
| 分类号 |
A61K38/55;A61K;A61K31/00;A61K38/00;A61K38/05;A61P7/00;A61P7/02;A61P9/10;A61P43/00;C07D487/04;C07D491/04;C07D495/04;C07K;C07K1/02;C07K5/00;C07K5/02;C07K5/06;C07K5/065;C12N9/99;(IPC1-7):A61K38/06;C07K5/08 |
主分类号 |
A61K38/55 |
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