THROMBIN DERIVATIVES AND PROCESS FOR PRODUCING THE SAME, ANHYDROTHROMBIN DERIVATIVES AND PROCESS FOR PRODUCING THE SAME, PLATELET AGGLUTINATION-INDUCING COMPOSITIONS, METHOD OF INDUCING PLATELET AGGLUTINATION, CLINICAL TEST REAGENTS, CLINICAL TEST METHOD, THROMBOSIS INHIBITORS, ADSORBENT AND PROCESS FOR PRODUCING THE SAME,

摘要

Thrombin derivatives having a lowered fibrinogen activity and anhydrothrombin derivatives having a lowered fibrinogen activity are provided. Namely, thrombin derivatives wherein carboxyl of thrombin is modified; and anhydrothrombin derivatives wherein carboxyl of anhydrothrombin is modified. Because of having a lowered affinity for fibrinogen, these thrombin derivatives are usable as platelet agglutination-inducing compositions and specific coagulation reaction reagents for clinical tests, etc. By affinity chromatography with the use of anhydrothrombin as a ligand bonded to carboxyl, blood coagulation factor VIII can be more selectively purified. The anhydrothrombin derivatives having modified carboxyl exert a sufficient antithrombotic effect in a smaller amount than conventional anhydrothrombin does, which makes them usable as thrombosis inhibitors.