发明名称 |
Anti-CD3 immunotoxins and therapeutic uses therefor |
摘要 |
Recombinant immunotoxin polypeptides are described comprising a CD3-binding domain and a Pseudomonas exotoxin mutant, and in particular, comprising a single chain (sc) Fv as the CD3-binding moiety. A preferred species of the invention comprises scFv(UCHT-1)-PE38. Also disclosed are methods for the preparation of said immunotoxins; functionally equivalent immunotoxins which are intermediates in the preparation of the immunotoxins of the invention, as well as polynucleotide and oligonucleotide intermediates; methods for the prevention and/or treatment of transplant rejection and induction of tolerance, as well as treatment of autoimmune and other immune disorders, using the immunotoxins or pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising the immunotoxins or pharmaceutically acceptable salts thereof.
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申请公布号 |
US2002142000(A1) |
申请公布日期 |
2002.10.03 |
申请号 |
US20000480236 |
申请日期 |
2000.01.10 |
申请人 |
DIGAN MARY ELLEN;LAKE PHILIP;WRIGHT RICHARD MICHAEL |
发明人 |
DIGAN MARY ELLEN;LAKE PHILIP;WRIGHT RICHARD MICHAEL |
分类号 |
C12N15/09;A61K31/137;A61K31/27;A61K31/343;A61K31/42;A61K31/436;A61K31/52;A61K31/573;A61K31/664;A61K31/7056;A61K38/00;A61K39/104;A61K39/395;A61K47/48;A61P37/06;C07D261/18;C07D307/88;C07D473/38;C07D498/18;C07K14/21;C07K16/28;C07K19/00;(IPC1-7):A61K39/395;A61K39/40;A61K39/42;A61K39/44;C12P21/08;C07K16/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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