METHOD OF PREVENTING T CELL-MEDIATED RESPONSES BY MAP PROTEINS

摘要

A method of immunomodulating the T cell response in Staphylococcal bacteria is provided wherein an effective amount of the Map protein from Staphylococcus aureus is administered to a host to prevent or suppress the T cell response. The present method may be utilized with either the Map protein or an effecti ve subdomain of fragment thereof such as the Map10 or Map19 protein. The presen t invention is advantageous in that suppression or prevention of the T cell response in a host can prevent or ameliorate a wide variety of the pathogeni c conditions such as T cell lymphoproliferative disease and toxic shock syndro me wherein the overstimulation of T cell needs to be suppressed or modulated.