Anti-idiotypic antibodies against antibodies which inhibit the binding of immunoglobulin E to its high affinity receptors

摘要

Antibodies and antibody fragments which are anti-idiotypic to an antibody that interferes with the binding of the Cepsi3 region of IgE to its high affinity receptor (mimobodies), particularly, which are anti-idiotypic to BSW17 (BSW17-mimobodies) are described, as well as their use as pharmaceuticals, especially vaccines, in the treatment of IgE-mediated diseases.