| 摘要 |
<p>The amount of osteocalcin-derived fragments in a body fluid is measured by determining binding to said fragments of an immunological binding partner specific for a epitope located at the N or C terminus of a said fragment created upon cleavage of osteocalcin at said terminus during resorption of bone and which is not present in intact osteocalcin. The epitope may be created by cleavage by cathepsin K and may include an isomerised or optically inverted amino acid.</p> |
