| 摘要 |
<p>This invention provides methods for modulating phosphate homeostasis and renal phosphate transport by delivering agents that alter the expression of the FGF 23 gene or alter the activity of the FGF 23 protein. The methods of the invention are useful for modulating renal phosphate transport, alleviating oncogenic osteomalacia-associated symptoms and treating phosphate homeostasis-related disease. The invention further provides methods for reducing phosphate re-absorption by delivering to a subject FGF 23 protein or polynucleotides that encode this protein. In addition, the invention provides methods for detecting and monitoring expression of the FGF 23 gene, modulating the activity of cells associated with calcium or phosphate transport, and modulating the phenotype of a neoplastic cell associated with oncogenic osteomalacia. Finally, the invention provides methods for screening candidate agents to identify compositions that modify the activity of the FGF 23 gene and protein.</p> |
