发明名称 |
MODIFIED PEPTIDES WITH INCREASED POTENCY |
摘要 |
The present invention is concerned with modified biological peptides providing increased potency, prolonged activity and/or increased half-life thereof. The modification is made via coupling through an amide bond with at least one conformationally rigid substituent, either at the N-terminal of the peptide, the C-terminal of the peptide, on a free amino or carboxyl group along the peptide chain, or at a plurality of these sites. Those peptides exhibit clinical usefulness for example in treating states of insulin resistance associated with pathologies such as type II diabetes. |
申请公布号 |
WO0210195(A3) |
申请公布日期 |
2002.10.03 |
申请号 |
WO2001CA01119 |
申请日期 |
2001.08.02 |
申请人 |
THERATECHNOLOGIES INC.;GRAVEL, DENIS;HABI, ABDELKRIM;ABRIBAT, THIERRY |
发明人 |
GRAVEL, DENIS;HABI, ABDELKRIM;ABRIBAT, THIERRY |
分类号 |
A61K38/00;A61K38/04;A61K38/22;A61P3/10;C07K7/08;C07K7/23;C07K14/00;C07K14/47;C07K14/55;C07K14/575;C07K14/58;C07K14/585;C07K14/595;C07K14/60;C07K14/605;C07K14/635;C07K14/65;C07K14/655;C07K14/665;C07K14/675;C07K14/68;C07K14/695;C07K14/78 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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