| 摘要 |
The present invention relates to a new essential downstream component of the wingless signaling pathway. In particular, the invention relates to nucleoti de sequences of the Drosophila melanogaster daughter of legless (doll) gene, of its encoded proteins, as well as derivatives, fragments and analogues thereo f. The invention includes vertebrate and invertebrate homologues of the Doll protein, comprising proteins that contain a stretch of amino acids with similarity to the Drosophila Doll gene. Methods for producing the Doll protein, derivatives and analogs, e.g. by recombinant means, and antibodies to Doll are provided by the present invention as well. The invention also relat es to methods for performing high throughput screening assays for compounds modulating Doll function in the Wnt pathway.
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