A process for efficiently and continuously producing a lactam in high-temperature high-pressure water, characterized by comprising: introducing an oxime as a substrate and an acid into a reaction zone through which high-temperature high-pressure water is flowing or introducing an oxime into high-temperature high-pressure water which contains an acid and is flowing; and thereby elevating the temperature of the substrate in a short time under the given high-temperature high-pressure conditions and reacting it to efficiently synthesize a lactam while inhibiting hydrolysis of the oxime. In the process, a lactam can be efficiently and continuously synthesized at a high rate from an oxime with the aid of an acid catalyst in high-temperature high-pressure water having a temperature of 250 DEG C or higher and a pressure of 15 MPa or higher.
申请公布号
WO02076942(A1)
申请公布日期
2002.10.03
申请号
WO2002JP02029
申请日期
2002.03.05
申请人
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE;HATAKEDA, KIYOTAKA;SATO, OSAMU;IKUSHIMA, YUTAKA;TORII, KAZUO