IMMUNOGENIC CELL SURFACE PROTEINS OF HELICOBACTER PYLORI

摘要

A method of identifying immunogenic Helicobacter pylori-specific surface proteins binding specifically to polysulphated molecules, is described. Further, a Helicobacter pylori-specific surface protein product, and a protein contained therein, binding specifically to polysulphated molecules are disclosed. Examples of such proteins are a protein having a MW of 30 (31.3) kDa, a (pI) of 9.3 (9.1) and comprising SEQ ID NO: 1 and/or SEQ ID NO: 2; a protein having a MW of 26 (27.7), a pI of 9.1-9.3 (9.0) and comprising SEQ ID NO: 4; or a protein having a MW of 25 (28.7), a pI of 9.0 (8.8) and comprising SEQ ID NO: 5.Additionally, use of a protein or protein product of the invention as a diagnostic antigen and as a component in a vaccine against H. pylori infection, as well as an immunoassay and a vaccine composition against a H. pylori infection, are described.