发明名称 |
PEPTIDE ANALOGUES OF MYELIN BASIC PROTEIN EPITOPES IN THE TREATMENT OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE) AND MULTIPLE SCLEROSIS (MS) |
摘要 |
This invention relates to novel linear and cyclic peptide analogues of Myeli n Basic Protein epitopes (from guinea pig MBP72-85 and human MBP87-99) and the ir conjugates with mannan and/or KLH useful in the treatment of Experimental Autoimmune Encephalomyelitis (EAE) and Multiple Sclerosis (MS). For the firs t time cyclic analogues of MBP epitopes have been synthesized and shown to prevent the development of EAE. There is gathering evidence that analogues o f disease-associated epitopes can be conjugated to mannan and/or KLH and actively generate antigen specific regulatory CD4/CD8 T cells and Th1/Th2 cytokines.
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申请公布号 |
CA2445640(A1) |
申请公布日期 |
2002.10.03 |
申请号 |
CA20012445640 |
申请日期 |
2001.03.23 |
申请人 |
MATSOUKAS, JOHN |
发明人 |
MATSOUKAS, JOHN;TSELIOS, THEODORE;APOSTOLOPOULOS, VASSO |
分类号 |
A61K38/00;A61K47/48;C07K14/47;(IPC1-7):C07K14/47;A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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